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    • cheese_greater@lemmy.worldOP
      2·
      7 months ago

      I gotta sleep soon aha but I’ll leave you with a last question for tonight: what do you think mediates Apigenin’s efficacy for sleep? Like what is the mechanism behind its efficacy, what systems does it modulate?

      Thanks and no rush, I’ll listen to that article tomorrow :)

      • Chetzemoka
        2·
        7 months ago

        So, it’s interesting, because it’s well-known to have effects on the same GABA receptors as benzodiazepines (like Xanax), but none of the addictive, physical dependence problems, and apigenin doesn’t respond consistently to the drug we use to reverse benzos (called flumazenil).

        So… we’re not entirely sure? It could still be the GABA effects that help with sleep. But there’s also a host of antiinflammatory neurological effects that probably better explain its efficacy against Alzheimer’s, for example.

        Now, if you really want to put yourself to sleep, feel free to crawl through this alphabet soup of a research article lol:

        https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6472148/

        • cheese_greater@lemmy.worldOP
          2·
          7 months ago

          Thanks and I will check those out. Does the flumazenil displace GABA_B ligands/receptors as well or only _A?

          Thats all for tonight, night

          • Chetzemoka
            2·
            7 months ago

            Oh you’re getting in the weeds now hahaha. Looks like it’s primarily GABA_A

            https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5326685/

            I just had to look that shit up haha. I’ve never thought to check into it beyond just “you’re not breathing, so I’m about to make you very angry by reversing your high, sorry bro” lol

            • cheese_greater@lemmy.worldOP
              2·
              7 months ago

              It seems as if _B ligands are both way less ubiquitous and also variably less-reinforcing than traditional alcohol-type sedatives like benzos/barbs/sleeps, although I say that very conjecturally (is that a word? Aha). And less likely to be overdone to the point the therapeutic window is being dangerously exceeded or a polypharmacy situation that leads to medical emergency like that

              From my own experience with baclofen which I used to wean off drinking and help with the induced anxiety, I didn’t really find it super pleasent or enjoyable and there were enough annoying sides like tearing up and a crappy fuzziness that was super offputting. Alcohol and sedatives (especially sleeping pills), totes different story (I find them as a class GABA_A way more dangerous and mindlessly compulsive.

              • Chetzemoka
                2·
                7 months ago

                Huh, now that’s super interesting.

                Ok you and I both have to go to sleep, but now you’ve got me wondering about the eternal debate amongst our medical residents about benzos vs. barbiturates for acute alcohol withdrawal. I’ll have to read up on this some more

                • cheese_greater@lemmy.worldOP
                  1·
                  7 months ago

                  Yeah, ask about baclofen, its famously advocated by a French dr who struggled to find a proper treatment for his alcoholism until he arrived on baclofen. End of My Addiction is the title.

                  I used it as an adjuvant treatment along with naltrexone and careful timing in terms of the actual drinking that was required to make the naltrexone effective in addressing the neurochemical basis for much of the compulsion from alcohol.