The comic basically says:

Users: Please run Reddit decently and do stuff people have told you to do for so long.

u/spez: Fuck you. We need to become profitable and to do that the API has to be shut down.

Users: Then, with the enshittification of this website, with the horrible management of once a great land, Reddit will crumble when the IPO approaches and investors get their hands on it. So just go to Lemmy where none of this is happening lmao